Fig. 2.

3D homology model of human SLC6A9, based on the dopamine transporter (PDB 4xpa). The dopamine analogue 3,4-dichlorophenethylamine (yellow), sodium (magenta), and chloride (cyan) ions have been taken over from the dopamine receptor structure that served as template. The bound ions are expected to be located in the wild-type (but not the S406 mutant) SLC6A9, as they are in the dopamine transporter, because of strict conservation of the ion-binding site. However, the dopamine analogue is of course replaced by glycine in SLC6A9, and the dopamine analogue is only displayed to illustrate the location of S406 with respect to the ligand molecule