Table 2.
HRs of FGF23 for Cause-Specific Mortality
| Deaths, n | Incidencea | Model 1c |
Model 2d |
Model 3e |
||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||
| Vascular death | ||||||||
| ln FGF23b | 474 | 15.0 | 1.54 (1.36, 1.74) | <.001 | 1.43 (1.25, 1.63) | <.001 | 1.38 (1.19, 1.60) | <.001 |
| Quintile 1 | 69 | 9.7 | Reference | Reference | Reference | |||
| Quintile 2 | 80 | 12.1 | 1.29 (0.94, 1.79) | .120 | 1.22 (0.88, 1.69) | .24 | 1.32 (0.92, 1.91) | .133 |
| Quintile 3 | 88 | 13.4 | 1.39 (1.01, 1.90) | .044 | 1.28 (0.93, 1.76) | .137 | 1.27 (0.88, 1.84) | .194 |
| Quintile 4 | 92 | 14.7 | 1.27 (0.92, 1.75) | .143 | 1.02 (0.74, 1.42) | .89 | 1.00 (0.69, 1.47) | .98 |
| Quintile 5 | 145 | 29.2 | 2.55 (1.89, 3.43) | <.001 | 2.07 (1.53, 2.81) | <.001 | 2.07 (1.45, 2.94) | <.001 |
| P for trend | <.001 | <.001 | <.001 | |||||
| Nonvascular death | ||||||||
| ln FGF23b | 612 | 19.4 | 1.59 (1.44, 1.77) | <.001 | 1.52 (1.36, 1.69) | <.001 | 1.43 (1.27, 1.62) | <.001 |
| Quintile 1 | 106 | 14.8 | Reference | Reference | Reference | |||
| Quintile 2 | 99 | 15.0 | 1.06 (0.80, 1.39) | .70 | 1.03 (0.78, 1.36) | .82 | 1.03 (0.76, 1.39) | .85 |
| Quintile 3 | 97 | 14.8 | 1.06 (0.80, 1.39) | .71 | 1.05 (0.79, 1.38) | .76 | 1.02 (0.75, 1.38) | .92 |
| Quintile 4 | 147 | 23.5 | 1.49 (1.15, 1.92) | .002 | 1.42 (1.09, 1.85) | .010 | 1.40 (1.05, 1.88) | .024 |
| Quintile 5 | 163 | 32.8 | 2.07 (1.60, 2.66) | <.001 | 1.92 (1.48, 2.49) | <.001 | 1.64 (1.22, 2.20) | .001 |
| P for trend | <.001 | <.001 | <.001 | |||||
| Cancer death | ||||||||
| ln FGF23b | 233 | 7.4 | 1.42 (1.19, 1.71) | <.001 | 1.34 (1.11, 1.62) | .002 | 1.32 (1.08, 1.62) | .010 |
| Quintile 1 | 41 | 5.7 | Reference | Reference | Reference | |||
| Quintile 2 | 45 | 6.8 | 1.27 (0.83, 1.94) | .27 | 1.26 (0.82, 1.93) | .29 | 1.31 (0.82, 2.08) | .26 |
| Quintile 3 | 35 | 5.3 | 1.02 (0.65, 1.61) | .92 | 1.00 (0.63, 1.58) | .99 | 1.04 (0.63, 1.70) | .89 |
| Quintile 4 | 55 | 8.8 | 1.64 (1.08, 2.47) | .019 | 1.64 (1.07, 2.51) | .022 | 1.72 (1.08, 2.74) | .022 |
| Quintile 5 | 57 | 11.5 | 2.11 (1.40, 3.19) | <.001 | 2.02 (1.32, 3.09) | .001 | 1.88 (1.17, 3.04) | .010 |
| P for trend | <.001 | <.001 | .010 | |||||
a
Incidence per 1000 person-years.
b
Per 1 U increases in ln FGF23.
c
Model 1: adjusted for age, sex, and race/ethnicity.
d
Model 2: adjusted for covariates in model 1 plus traditional cardiovascular disease risk factors (cigarette smoking, body mass index, hypertension, diabetes, hypercholesterolemia, prevalent cardiovascular disease) and eGFR.
e
Model 3: adjusted for covariates in models 1 and 2 plus mineral metabolism markers (phosphate, PTH, 25-hydroxyvitamin D, calcium, and albumin).