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. 2016 Jul 26;101(10):3787–3793. doi: 10.1210/jc.2016-2069

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This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is reatined by the author(s).

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Figure 2. — The effect of metformin on 11βHSD1 activity in vivo. Data are expressed as mean ± SEM for the effect of metformin (black columns), gliclazide (bricked columns), and placebo (white columns) on the Ra of cortisol (A) and D3-cortisol (B) during steady state. C, The effect of metformin (black squares), gliclazide (open triangles), and placebo (open circles) on Ra cortisol after 5 mg oral cortisone ingestion in the ODM group. Phases were compared using paired t tests in the OND group and repeated measures ANOVA with post hoc Fisher's LSD testing in the ODM group. Placebo-phase data in OND and ODM groups were compared using the unpaired t test. *, P < .05 vs placebo; $, P < .05 vs metformin; #, P < .05 vs OND group.