Table 4.
Percentage Difference in Bone Outcomes per 10 Years of HRT Use, Unadjusted, and Then Adjusted for Type of Menopause and Additionally Adjusted for Current Height (Meters) and Weight (Kilograms)
| Unadjusted |
Model 2 |
Model 3 |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Adjusted for Type of Menopause |
Adjusted for Type of Menopause, Height and Weight |
||||||||
| Difference, % | 95% CI | P Value | Difference, % | 95% CI | P Value | Difference, % | 95% CI | P Value | |
| Diaphysis CSA (n = 603) | 1.9 | −0.4 to 4.2 | .1 | 1.8 | −0.6 to 4.2 | .1 | 2.4 | 0.3–4.5 | .03 |
| Medullary CSA (n = 602) | −6.5 | −12.2 to −0.7 | .03 | −5.7 | −11.7 to 0.2 | .06 | −5.5 | −11.4 to 0.4 | .07 |
| Total vBMD (n = 597) | 3.3 | −0.3 to 6.8 | .07 | 2.3 | −1.3 to 6 | .2 | 3.0 | −0.6 to 6.7 | .1 |
| Trabecular vBMD (n = 596) | 4.0 | −0.3 to 8.3 | .07 | 2.9 | −1.6 to 7.3 | .2 | 3.8 | −0.6 to 8.2 | .09 |
| Cortical vBMD (n = 604) | 0.9 | 0.4–1.5 | .001 | 0.9 | 0.3–1.5 | .003 | 0.9 | 0.3–1.5 | .002 |
| Polar SSI (n = 604) | 6.0 | 2.6–9.3 | <.001 | 5.4 | 1.9–8.9 | .003 | 6.3 | 3.1–9.4 | <.001 |
| Spine L1-L4 aBMD (n = 747) | 4.0 | 1.4–6.5 | .002 | ||||||
| Ceased naturally | 5.3 | 2.1–8.5 | .001 | 6.7 | 3.7–9.7 | <.001 | |||
| Ceased surgically | −1.4 | −6.1 to 3.2 | .5 | 0.6 | −3.9 to 5.0 | .8 | |||
| Hip aBMD (n = 742) | 1.8 | −0.4 to 3.9 | .1 | 0.7 | −1.5 to 3 | .5 | 2.8 | 0.8–4.7 | .007 |
P = .02 for the interaction between type of menopause and length of HRT.