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. 2015 Nov 30;40(4):359–365. doi: 10.1016/j.jgr.2015.11.003

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Copyright 2016, The Korean Society of Ginseng, Published by Elsevier.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Effects of ginsenoside Ro (G-Ro) on thrombin-induced fibrinogen binding. (A) The flow cytometry histograms on fibrinogen binding. a, intact platelets (base); b, thrombin (0.05 U/mL); c, thrombin (0.05 U/mL) + G-Ro (50μM); d, thrombin (0.05 U/mL) + G-Ro (100 μM); e, thrombin (0.05 U/mL) + G-Ro (200μM); f, thrombin (0.05 U/mL) + G-Ro (300 μM); g, thrombin (0.05 U/mL) + eptifibatide (50μM); and h, thrombin (0.05 U/mL) + GR 144053 (50μM). (B) Effects of G-Ro on thrombin-induced fibrinogen binding. Its binding degree (%) is from Fig. 4A. Determination of fibrinogen binding to glycoprotein IIb/IIIa (αIIb/β₃) was carried out as described in the “Materials and methods” section. Data are presented as mean ± standard deviation (n = 4). * p < 0.05 versus the thrombin-stimulated human platelets. FL1-H, fluorescent light-1 height.