Fig. 5.

Effects of ginsenoside Ro (G-Ro) on thrombin-induced fibrinogen binding in the presence of an A-kinase inhibitor (Rp-8-Br-cAMPS). (A) The flow cytometry histograms on fibrinogen binding. Thrombin (0.05 U/mL) + G-Ro (300μM) + Rp-8-Br-cAMP (250μM). (B) Effects of G-Ro on thrombin-induced fibrinogen binding in the presence of the A-kinase inhibitor (Rp-8-Br-cAMPS). Its binding degree (%) is from Fig. 4, Fig. 5A. Determination of fibrinogen binding to αIIb/β₃ was carried out as described in the “Materials and methods” section. Data are presented as mean ± SD (n = 4). * p < 0.05 versus the thrombin-stimulated human platelets. ** p < 0.05 versus the thrombin-stimulated human platelets in the presence of G-Ro (300μM). FL1-H, fluorescent light-1 height.