Fig. 3.

Rb1 and CK inhibit ER stress in adipose tissue. Mice were sacrificed by cervical dislocation, and epididymal adipose tissue was separated. The tissue was pretreated with Rb1 (10μM), CK (10μM), or TUDCA (200μM), and then cultured with high glucose (33mM) for 24 h. IRE1α (A) and PERK (B) phosphorylation was determined by western blot. The results were expressed as the mean ± SD of three independent experiments. *p < 0.05 versus high glucose-only treatment. CK, ginsenoside compound K; ER, endoplasmic reticulum; SD, standard deviation; TUDCA, tauroursodeoxycholic acid.