Figure 2. Dendrogram derived by clustering SIFts.

(A) Dendrogram derived by agglomerative hierarchical clustering of SIFt of PPARγ partial agonists and VS hits. Tanimoto similarity coefficient was used to calculate similarity between the SIFts. (B) Binding mode of VS hits belonging to cluster 1 (left), cluster 2 (middle) and cluster 3 (right). Some representatives of structures are shown.