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(A) Superposition of PPARγ complexes (gray) with known partial agonists (pdb codes: 3D6D, 4PVU, 4PWL, 4JL4, 4JAZ, 4E4K, 2Q5P, 2Q6S, 2Q5S, 4E4Q, 5F9B) onto the PPARγ complex with AL29-26 (cyan). The carboxylate groups are depicted in red, the residue S342 in blue. (B) Superposition of SR2067 (magenta) (pdb code 4R06) onto the PPARγ complex with AL29-26 (cyan). The red arrow indicates the naphthalene groups of the two ligands.
