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. 2016 Oct 6;6:34792. doi: 10.1038/srep34792

Figure 5. Comparison of PPARα complexes.

Figure 5

(A) Superposition of PPARα complexes (gray) with known partial agonists (pdb codes: 2REW, 4BCR, 1K7L, 3SP6, 3FEI, 2GTK, 3G8I, 3ET1, 3KDT, 1I7G) onto the PPARα complex with AL29-26 (ligand yellow, protein cyan). The ligand BMS-631707 (PDB code 2REW) is shown in green. The “closed” (trans) conformation of F273 side-chain is also shown (gray). (B) New conformation of the loop 11–12 in the PPARα/AL29-26 complex: superposition of the loops 11–12 of known PPARα structures (light-brown) (same pdb codes of Fig. 5A) with that of PPARα/AL29-26 (ligand yellow, protein cyan). The ligand BMS-631707 (PDB code 2REW) is shown in green. Additional vdW interactions realized by AL29-26 are shown as red dashed lines.