Table 1.

Study Medications and Their eGFR Thresholds and Maximum Daily Dose/Contraindication Status

Medication	eGFR Threshold (mL/min)	Maximum Daily Dose/Contraindication Status
Amantadine	<50	100 mg
	<30	50 mg
	<15	29 mg
Ciprofloxacin	<30	500 mg
Colchicine	<30	0.3 mg
Dabigatran1	<30	contraindicated
Dofetilide1	40 – <60	500 µg
	20 – <40	250 µg
	<20	contraindicated
Enoxaparin1	<30	contraindicated
Famciclovir	40 – <60	1000 mg
	20 – <40	500 mg
	<20	250 mg
Fondaparinux1	<30	contraindicated
Gabapentin	30 – 44	1200 mg
	15 – 29	600 mg
	<15	300 mg
Glyburide	<51	contraindicated
Levofloxacin	20 – <50	250 mg (most cases)
		375 mg (complicated / pneumonia)
	<20	125 mg
Metoclopramide	<40	20 mg
NSAID1,2	<40	contraindicated
Sotalol1	30 – <60	administer q 24 hours
	10 – <30	administer q 36–48 hours
	<10	individualize dose
Spironolactone	<10	contraindicated
Trimethoprim/	15 – <30	DS
Sulfamethoxazole	<15	contraindicated
Trimethoprim	15 – <30	100
	<15	not recommended

¹ High risk medications that are contraindicated at a certain eGFR; medication dose adjustments were made with actual creatinine clearance and body weight

² Includes ibuprofen, celecoxib, etodolac, flubiprofen, indomethacin, ketoprofen, ketorolac, meloxicam, nabumetone, naproxen, sulindac, and tolmetin