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. 2016 Oct 6;6:34701. doi: 10.1038/srep34701

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Copyright © 2016, The Author(s)

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(a) SPR measurements for compounds 8, 10–22 on WT-HSC70-NBD were carried out in triplicate unless otherwise stated. Compounds did not bind to the S275W HSC70-NBD mutant. SPR K_d values are expressed as a mean ± standard deviation or standard error. ^aDuplicate measurement. ^bSingle measurement. ^cLigand efficiency is calculated using the SPR K_d. ^dNot Determined. (b) Synthesis of cyclopentylaminotriol analogues 23, 24 and 26 (c) SAR of cyclopentylaminotriol analogues. SPR measurements on WT-trHSC70 were carried out in triplicate. Compounds did not bind to the S275W HSC70-NBD mutant. SPR K_d values are expressed as a mean ± standard deviation or standard error. ^aLigand efficiency is calculated using the SPR K_d.