Table 3. Performance (%) comparison on the partial- and full-length testing dataset.
Partial-length testing dataset |
Full-length testing dataset |
||||||||
---|---|---|---|---|---|---|---|---|---|
CPAT | CNCI | PLEK | lncScore | CPAT | CNCI | PLEK | lncScore | ||
Human | Accuracy | 84.03 | 80.51 | 63.14 | 89.12 | 94.41 | 92.20 | 90.61 | 95.21 |
Sensitivity | 76.19 | 65.40 | 31.76 | 84.15 | 94.97 | 89.00 | 85.96 | 95.56 | |
PPV | 92.12 | 96.46 | 94.83 | 94.61 | 95.46 | 98.16 | 98.62 | 96.64 | |
Specificity | 92.75 | 97.33 | 98.07 | 94.67 | 92.75 | 97.33 | 98.07 | 94.67 | |
NPV | 77.78 | 71.65 | 56.36 | 84.29 | 92.00 | 84.64 | 81.31 | 92.99 | |
MCC | 69.41 | 65.36 | 39.07 | 78.85 | 87.59 | 84.55 | 81.96 | 89.93 | |
Mouse | Accuracy | 79.04 | 76.47 | 50.07 | 89.92 | 94.65 | 92.83 | 83.67 | 96.46 |
Sensitivity | 72.88 | 69.24 | 35.34 | 88.39 | 94.19 | 91.56 | 81.17 | 97.35 | |
PPV | 97.97 | 98.05 | 90.91 | 97.61 | 98.39 | 98.48 | 95.75 | 97.78 | |
Specificity | 95.88 | 96.23 | 90.35 | 94.08 | 95.88 | 96.23 | 90.35 | 94.08 | |
NPV | 56.40 | 63.37 | 33.82 | 74.78 | 86.05 | 80.98 | 64.18 | 92.99 | |
MCC | 61.15 | 58.02 | 25.21 | 77.27 | 84.21 | 83.52 | 65.47 | 91.10 |
The default cutoff of CPAT, PLEK, and lncScore is shown in Fig. 4, and the default cutoff of CNCI is 0.