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. 2016 Sep 27;7:12874. doi: 10.1038/ncomms12874

Figure 8. CARD9 acts as a regulatory switch during infection.

Figure 8

(a) Immunoblotting of CARD9 and ASC in cell lysates from unprimed WT BMDMs after infection with S. Typhimurium (m.o.i. 5) for 0, 30, 60 and 120 min. (b) Immunoblotting of CARD9 and ASC in cell lysates from unprimed BMDMs (WT, Card9−/− or Pycard−/−) after infection with S. Typhimurium (m.o.i. 5) for 0, 2 and 6 h. (c) Immunoblotting of CARD9 and ASC in cell lysates from uninfected, S. Typhimurium-infected (m.o.i. 5 for 2 h) or nigericin-stimulated (5 μM, 30 min) LPS-primed BMDMs (WT, Card9−/− or Pycard−/−). (a–c) Images are representative of three independent experiments.