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. 2016 Sep 27;7:12756. doi: 10.1038/ncomms12756

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Copyright © 2016, The Author(s)

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(a) Analysis of CD8-redirection. BM cells from WT and PKD2/3^ΔT mice were transferred into irradiated TAP^−/− recipient mice. At 8 weeks after BMT, CD4 and CD8 expression levels on TCRβ^hi thymocytes were analysed by flow cytometry. The percentage of gated population is indicated. (b) Real time PCR analysis of ThPOK, Runx3 and Runx3d mRNA expressions in CD4⁺CD8^int thymocytes. Results are presented as relative expression of β-actin. **P<0.01, NS, not significant. (c) Flow cytometry analysis of CD4 and CD8 expression on TCRβ^hi thymocytes from WT, PKD2/3^ΔT and PKD2/3^ΔT × ThPOK Tg mice. (d) CD5 expression on CD4 SP thymocytes. Data are presented as mean±s.d. of triplicate assays (b) and representative of two (a,b) or three (c,d) independent experiments. Unpaired two-tailed Student's t test is used to calculate P values.