Table 4.
Monocytic and DC phenotype and strain differences.
| Common surface markers between B6.g7 and NOD mice | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| pDCs | cDC1s | cDC2s | Monocytes | moDCs | ||||||
| B220 | + | − | − | − | − | |||||
| BST2 | + | − | − | − | − | |||||
| CD4 | + | − | + | − | − | |||||
| CD8α | lo−hi | hi | − | − | − | |||||
| CD24 | − | + | − | − | − | |||||
| CD36 | − | + | − | − | + | |||||
| CD103 | − | + | − | − | − | |||||
| CD205 | − | + | − | − | − | |||||
| CD206 | − | + | − | − | ± | |||||
| CD209 | − | − | − | − | ± | |||||
| Clec9a | − | + | − | − | − | |||||
| DCIR2 | − | − | + | − | − | |||||
| MHCII | int | hi | hi | − | hi | |||||
| Siglec–H | + | − | − | − | − | |||||
| Varying surface markers between B6.g7 and NOD mice
| ||||||||||
| pDCs
|
cDC1s
|
cDC2s
|
Monocytes
|
moDCs
|
||||||
| Strain: | B6 | NOD | B6 | NOD | B6 | NOD | B6 | NOD | B6 | NOD |
|
| ||||||||||
| CD11b | − | − | − | − | 903* | 618 (0.68)** | 4025 | 5347 (1.33) | 3719 | 4218 (1.13) |
| CD11c | 885 | 1687 (1.91) | 7994 | 9563 (1.20) | 8320 | 12928 (1.55) | − | − | 2035 | 1656 |
| CD64 | − | − | 217 | − | − | − | 611 | − | 268 | − |
| CD172a | 268 | 419 (1.56) | − | − | 505 | 797 (1.58) | 424 | 600 (1.42) | 443 | 480 |
| Ly6C | + | −/+ | − | − | − | − | 55042 | 17232 (0.31) | − | − |
*
Numbers provided are the average MFIs from 3 different mice.
*
When the difference between B6.g7 and NOD populations are statistically significant, the fold difference can be found in parentheses.