Table 1. Genome-wide significant association of 6q25.3 with acute otitis media.
| SNP | Chr | Pos (hg19) | Gene | A1/A2 | MAF cases/controls | Stage | ORCHOP(95% CI) | PCHOP | ORGenR (95% CI) | PGenR | Pmeta |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs2932989 | 6 | 159699284 | FNDC1 | T/G | 0.17/0.13 | Discovery | 1.41 (1.23, 1.62) | 1.46e−06 | 1.25 (1.05, 1.48) | 1.02e−02 | 4.36e−08* |
| Replication | 1.35 (1.05, 1.73) | 1.55e−02 | |||||||||
| Combined | 2.15e−09† |
A1, minor allele; A2, major allele; Chr, chromosome; CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; P, P value; Pos, position; SNP, single-nucleotide polymorphism.
*P value of meta-analysis at discovery stage.
†P value of meta-analysis of all cohorts.