Table 1.
Patient characteristics
| All | Responders | Non-responders | ||
|---|---|---|---|---|
| n = 33 | n = 10 | n = 23 | p | |
| Age | 60.0 (13.6) | 58.4 (16.2) | 60.7 (12.7) | 0.70 |
| Sex | ||||
| Male | 15 (45 %) | 4 (40 %) | 11 (48 %) | 0.97 |
| Female | 18 (55 %) | 6 (60 %) | 12 (52 %) | |
| Weight (kg) | 72.1 (12.9) | 75.0 (14.1) | 70.9 (12.4) | 0.44 |
| APACHE II score | 19.9 (6.9) | 19.0 (5.8) | 20.4 (7.5) | 0.58 |
| Died in hospital | ||||
| Yes | 16 (48 %) | 7 (70 %) | 9 (39 %) | 0.21 |
| No | 17 (52 %) | 3 (30 %) | 14 (61 %) | |
| Admission to PLR (h) | 26 [18, 52] | 38 [21,102] | 26 [16, 42] | 0.25 |
| Arrhythmia | ||||
| Present | 3/32 (9 %) | 1/9 (11 %) | 2/23 (9 %) | 1.00 |
| Absent | 29/32 (91 %) | 8/9 (89 %) | 21/23 (91 %) | |
| Tidal volume (ml) | 510 [463, 563] | 540 [473, 660] | 491 [460, 549] | 0.39 |
| Plateau pressure (cmH2O) | 26.6 (7.1) | 26.4 (5.5) | 26.7 (7.7) | 0.90 |
| PEEP (cmH2O) | 8.5 (2.5) | 8.9 (2.8) | 8.4 (2.4) | 0.60 |
| Respiratory rate (/min) | 16.8 (4.2) | 15.5 (2.4) | 17.3 (4.7) | 0.15 |
| Spontaneous breathing | ||||
| Yes | 6/30 (20 %) | 2/9 (22 %) | 4/21 (19 %) | 1.00 |
| No | 24/30 (80 %) | 7/9 (78 %) | 17/21 (81 %) | |
| Arterial line site: | ||||
| Femoral | 4 (12 %) | 1 (10 %) | 3 (13 %) | 1.00 |
| Other (radial and brachial) | 29 (88 %) | 9 (90 %) | 20 (87 %) | |
| Diagnostic groups: | ||||
| Septic shock | 27 (82 %) | 7 (70 %) | 20 (87 %) | 0.34 |
| – Endocarditis | 1 (3 %) | 0 (0 %) | 1 (4 %) | – |
| – Occult | 7 (21 %) | 2 (20 %) | 5 (22 %) | – |
| – Peritonitis | 8 (24 %) | 2 (20 %) | 6 (26 %) | – |
| – Pneumonia | 11 (33 %) | 3 (30 %) | 8 (35 %) | – |
| SIRS | 6 (18 %) | 3 (30 %) | 3 (13 %) | – |
| – Ischaemic bowel | 2 (6 %) | 1 (10 %) | 1 (4 %) | – |
| – Occult | 1 (3 %) | 0 | 1 (4 %) | – |
| – Pancreatico-duodenectomy | 1 (3 %) | 0 | 1 (4 %) | – |
| – Pancreatitis | 2 (6 %) | 2 (20 %) | 0 | – |
Data are shown as mean (standard deviation), median (inter-quartile range), or number (percentage) with p value comparing responders to non-responders for certain characteristics. Sample sizes are as in column headings unless stated (some variables had small numbers of missing values)