Table 1.

Mixed-Model Analyses of CDSS Least Squares Means Across Treatment Groups and Interaction Between Treatment and Being in a Major Depressive Episode (MDE) at Baseline^a

						Main Effect of Treatment Group		Interaction of Treatment Group by MDE		Paired Comparisonb
	Olanzapine (O)	Perphenazine (P)	Quetiapine (Q)	Risperidone (R)	Ziprasidone (Z)	F	P	F	P	F	P
Total n	328	256	326	332	182
Dataset 1 (df= 3): P vs O, Q, and R (excluding patients with tardive dyskinesia and those taking Z)
n	263	256	261	269
Mean CDSS
Total sample	3.80	3.80	3.67	3.96		0.79	.50	3.32	.02
No MDE	2.28	2.44	2.35	2.33
MDE	8.95	8.71	8.51	9.11							NS
Dataset 2: O vs Q vs R (including patients with tardive dyskinesia but excluding those taking Z or P)
n	328		326	332
Mean CDSS
Total sample	3.73		3.73	3.97		1.43	.24	2.90	.05
No MDE	2.28		2.12	2.42
MDE	8.78		8.52	9.06						2.9; Q < R	.0056*
Dataset 3: Z vs P (excluding patients with tardive dyskinesia but including those taking Z)
n		146			150
Mean CDSS
Total sample	3.23	3.73	3.84	3.84	4.23	1.30	.27	1.86	.11
No MDE	2.45	2.53	2.27	2.47	2.48
MDE	9.07	8.63	8.55	8.70	9.34						NS
Dataset 4: Z vs O, Q, and R (including patients with tardive dyskinesia and those taking Z)
n	177		181	174	178
Mean CDSS
Total sample	3.86		3.68	3.77	3.89	0.37	.77	0.75	.15
No MDE	2.41		2.28	2.41	2.32
MDE	8.88		8.61	8.91	9.29						NS

^aLeast squares means of CDSS scores from months 1, 3, 6, 9, 12, 15 (4,816 patient month observations for data set 1; 4,480 for data set 2; 1,285 for data set 3; and 3,802 for data set 4).

^bAll pairwise P values < .05 are presented.

^*Statistically significant using criteria for multiple comparisons.

Abbreviations: CDSS = Calgary Depression Scale for Schizophrenia, NS = nonsignificant.