Table 3.
Correlation between C4d, C3bBbP, sTCC and other biomarkers in the recent injury group
| Biomarkers | n | C4d | C3bBbP | sTCC |
|---|---|---|---|---|
| IL-1β | 112 | 0.397 (<0.001) | 0.232 (0.014) | 0.297 (0.001) |
| IL-6 | 112 | 0.364 (<0.001) | 0.235 (0.013) | 0.268 (0.004) |
| IL-8 | 112 | 0.355 (<0.001) | 0.183 (0.054) | 0.372 (<0.001) |
| TNF-α | 112 | 0.547 (<0.001) | 0.317 (0.001) | 0.391 (<0.001) |
| sGAG | 181 | 0.108 (0.148) | 0.092 (0.218) | 0.132 (0.077) |
| ARGS | 111 | −0.023 (0.811) | −0.113 (0.238) | 0.176 (0.065) |
| COMP | 112 | −0.019 (0.845) | −0.149 (0.116) | −0.057(0.549) |
| C2C | 164 | −0.181 (0.020) | −0.101 (0.197) | −0.085 (0.279) |
| Osteocalcin | 112 | 0.265 (0.005) | 0.192 (0.043) | 0.016 (0.871) |
| SPARC | 112 | 0.476 (<0.001) | 0.221 (0.019) | 0.401 (<0.001) |
| Osteopontin | 112 | 0.167 (0.079) | 0.098 (0.302) | 0.165 (0.083) |
Abbreviations: IL Interleukin, TNF-α Tumour necrosis factor α, sGAG Sulfated glycosaminoglycan, ARGS ARGS-aggrecan, COMP Cartilage oligomeric matrix protein, C2C Type II collagen epitope, SPARC Secreted protein acidic and rich in cysteine, sTCC Soluble terminal complement complex
Correlation using Spearman rho (r s), between synovial fluid biomarkers was analysed in samples from the recent injury group (0–83 days after injury). Significant correlations (p < 0.05) are shown in boldface type. The table shows r s with p values in brackets. References to biomarkers: cytokines, ARGS, sGAG, osteocalcin, SPARC, osteopontin [14], COMP [19], C2C [23]