Fig. 1.

Astrocytic transcriptomic alterations after SCI. Venn diagrams indicating the number of deregulated genes in FACSed astrocytes (a–c) at different stages after HS and FT. Relationship between average gene expression and log fold-change in astrocytes (d–g) at different stages after HS and FT injuries. Bar graphs displaying astrocytic involvement in different pathways (h–k) at multiple time-points after HS and FT SCI. At 1 week after FT, astrocytes predominantly over-express genes that are involved in immune response and inflammation (h & i). At 2 weeks after FT, astrocytes down-regulate the expression of transcripts involved in connective tissue degradation and cytoskeleton re-organization (j & k). Values are log fold change (d–g) and actual fold change (h–k) ± SEM (*p < 0.05; **p < 0.01; ***p < 0.001 by un-paired t test)