Table 2.

Functional measures and endpoints

Time point	Study	Domain	Endpoint
Baseline, 3, 6, 12, 18 and 24 months	MDADI	Swallowing related QoL	Composite (total), global, emotional, functional and physical subscale scores
Baseline, 3, 6, 12, 18 and 24 months	WST	Swallow Performance	Swallow capacity, Swallow volume
Baseline, 12 and 24 months	VFa	Airway protection	Penetration Aspiration Scale [52]
Baseline, 12 and 24 months	VFa	Physiology	MBSImp
Baseline, 12 and 24 months	VFa	Pharyngeal dysphagia grade	DIGEST grade [53]
Baseline, 3, 6, 12, 18 and 24 months	PSS-HN	Functional Performance Status	Normalcy of diet, eating in public, understandability of speech scores
Baseline, 3, 6, 12, 18 and 24 months	UW-Qol v.04	HR-QoL	Composite scores of physical and social-emotional functioning are derived from 12 domains. Patients can also highlight up to 3 priority concerns from the previous 7 days

Abbreviations: WST Water Swallowing Test, DIGEST Dynamic Imaging Grade of Swallowing Toxicity, MBSImp Modified Barium Swallow Impairment Profile

^aSubset of centres only