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. 2016 Oct 6;18:224. doi: 10.1186/s13075-016-1128-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Expression of anti-citrullinated protein antibodies (ACPA) and ligands of toll-like receptor 4 in samples of synovial fluid (SF) from patients with rheumatoid arthritis (RA) and correlation between these and NI-0101 response. a Expression of ACPA, HMGB1 and S100A8/A9 in SF from subjects without RA (non-RA SF) (n = 4 samples) and patients with RA (RASF) (n = 40 samples). b Correlation between ACPA, HMGB1 or S100A8/A9 and NI-0101 response. RASF samples were classified as NI-0101 non-responders (NR) or NI-0101 responders (R) according to Fig. 2. The Mann-Whitney U test was performed to test for differences among groups; *p < 0.05, **p < 0.01