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Sphingosine-1-phosphate (S1P) as an important regulatory molecule in cancer. S1P produced by SphK1 is exported from cancer cells via S1P transporters. It promotes cancer cell proliferation, invasion and survival by binding to specific G protein-coupled receptors (S1P receptors) in an autocrine and paracrine manner. S1P produced by cancer cells also stimulates S1P receptors on endothelial cells and promotes tumor-related angiogenesis and lymphangiogenesis
