Figure 7.

Role of miR-9 in zebrafish brain development.

Notes: (A) Zebrafish forebrain: In the forebrain, miR-9 inhibits proneural gene her6 and targets Fgf signaling pathway genes (dusp6, pea3). However, detailed study is not available on this account. (B) Zebrafish midbrain and hindbrain: The miR-9 regulates MHB by limiting Fgf8 and its receptor Fgfr1 expression within the MHB. The miR-9 regulates the progenitor state in the MH by regulating her5 and her9. (C) Zebrafish hindbrain: The miR-9 is regulated by Notch signaling and its target gene, her6. The miR-9 regulates proliferation by inhibiting Zic5 and differentiation by inhibiting elavl3.

Abbreviations: MH, midbrain–hindbrain; MHB, MH boundary; miR-9, miRNA-9.