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. 2016 Oct 6;20:315. doi: 10.1186/s13054-016-1499-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Increase in serum chloride and AKI severity. The mean increase in serum chloride (Δ[Cl^-]) in AKI stage 1, 2 and 3 is significantly higher than in patients without AKI (p < 0.05) and these data suggest a dose-response relationship between Δ[Cl^-] and AKI stage. Δ[Cl ^- ] increase in serum chloride, AKI acute kidney injury,