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. 2016 Oct 6;1(16):e89371. doi: 10.1172/jci.insight.89371

Figure 3. Effect of furin inhibition on the secretion and clotting activity of human factor VIIa (hFVIIa) and hFIX.

Figure 3

The amount of factor secreted from either FVIIa- (A) or FIX-producing (C) HEK293 cells after transduction with vectors containing either the furin-inhibiting α1-antitrypsin Portland (A1AT-PDX) or the negative control, A1AT-wild type (A1AT-WT). The amount of FVIIa activity (B) or FIX activity (D) from the same conditioned media. Each data point represents a distinct transduction. Means were compared by 2-tailed Student’s t test. P values greater than 0.05 were considered not significant (n.s.). Horizontal markers in whisker plots represent the mean and 1 SEM.