Figure 1.

(a) The overall structure of mouse GPx4 shown as a ribbon. The secondary-structure elements are coloured as follows: helices, magenta; β-strands, green; loops, grey. The catalytic tetrad, located at the top of the structure, is shown in cyan. (b) shows a 2F _o − F _c electron-density map contoured at 1σ for the catalytic tetrad residues. (a) and (b) were prepared using PyMOL (v.1.8; Schrödinger) and CueMol (http://www.cuemol.org/en), respectively.