Figure 3.
Effect of jabuticaba hydroalcoholic extract (JHE) and verapamil on the contractile response in isolated endothelium-denuded arteries. Cumulative concentration-response curves for CaCl2 were stimulated with phenylephrine (0.1µM) (A) or KCl 75 mM (B) in control conditions and after incubation (20 min) with JHE (IC50: 0.51 or IC100: 1.92 mg/mL) or verapamil (IC50: 0.3 µM). The points represent mean ± SEM of the contractile effect expressed as % contraction in relation to total KCl-induced contraction (75 mM). Significant difference: *** p<0.001 vs. Control.