Skip to main content
. 2016 Aug 1;64(11):1925–1937. doi: 10.1002/glia.23033

Figure 4.

Figure 4

Loss of Tgfbr2 in dendritic cells polarizes T cells to produce IFN‐γ. Levels of IL‐12p70 and IL‐23p19 in culture supernatants from (A) BMDMs and BMDCs stimulated for 24 h with the indicated cytokines. B: Experimental setup of BMDC and T cell coculture. C: Intracellular cytokine staining of CD4+ T cells from day 7 MOG‐CFA immunized mice after coculture with BMDCs and 20 µg MOG35‐55. BMDCs were pre‐stimulated for 2 h with the indicated cytokines. D: Soluble IFN‐γ in culture supernatants from LPS + TGFβ condition. Data are presented as means ± SEM. n = 3 mice/group. * P < 0.05 ** P < 0.01 *** P < 0.001 (A,C, one way ANOVA with Bonferroni post test; D, Student's unpaired t‐test).