Figure 2.

Blood smear findings in a transfusion dependent patient with pyruvate kinase deficiency before splenectomy (Figure 2A) and after splenectomy when no longer requiring red cell transfusions (Figure 2B). The red cell findings before splenectomy are mild, whereas, after splenectomy, polychromasia is more prominent and the characteristic echinocytes are more pronounced. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]