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. 2015 Aug 28;16(1):235–245. doi: 10.1111/ajt.13426

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© 2015 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of American Society of Transplant Surgeons

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Influence of HLA on development of type 1 diabetes recurrence. (A) Frequencies of T1D‐predisposing HLA variants among simultaneous pancreas–kidney recipients, according to group (HLA‐DR3/DR4, normal glucose tolerance [NGT] versus hyperglycemia with type 1 diabetes recurrence [HG‐T1DR], p = 0.02; RR = 2.16; OR = 3.5; positive predictive value [PPV] = 0.53; sensitivity = 0.17; specificity = 0.94). (B) Frequency of donor–recipient sharing for the HLA types shown. Statistical differences were found for sharing of any HLA‐DR (NGT versus HG‐T1DR, p = 0.002; RR = 3.2; OR = 6.14; PPV = 0.57; sensitivity = 0.97; specificity = 0.16) and of HLA‐DR3 (NGT versus HG‐T1DR, p = 0.003; RR = 1.6; OR = 5.1; PPV = 0.85; sensitivity = 0.94; specificity = 0.23). For both panels, significant p values are shown calculated with the Fisher's exact test.