Figure 2.

Plasminogen activator inhibitor‐1 (PAI‐1) restricts the outgrowth of Yersinia pestis in the absence of Pla. (A, B) Bacterial burden in the (A) lungs and (B) spleens of C57BL/6 or C57BL/6 PAI‐1 ^−/− mice infected with 10⁴ colony‐forming units (CFUs) of Y. pestis or Y. pestis ∆pla at the indicated times. Each point represents the numbers of bacteria recovered from a single mouse. An ‘X’ indicates a mouse that succumbed to the infection, the median number of CFUs is denoted by a solid line, and the dashed line indicates the limit of detection. Data from two independent experiments are combined (n = 10 for each group). The Mann–Whitney U‐test was used for comparison of bacterial burden measurements (***P ≤ 0.001). NS, not significant.