Figure 6.

Plasminogen activator inhibitor‐1 (PAI‐1) regulates cytokine production during pneumonic plague. Forty‐eight hours after inoculation with phosphate‐buffered saline (mock), 10⁴ colony‐forming units (CFUs) of Yersinia pestis, or 10⁴ CFUs of Y. pestis ∆pla, the levels of the indicated cytokines present in the bronchoalveolar lavage fluid of C57BL/6 or C57BL/6 PAI‐1 ^−/− mice were assessed by cytometric bead array. Data from two or three independent experiments are combined (n = 10–15 for each group); error bars represent standard errors of the mean. One‐way anova with Bonferroni's multiple comparison test was used to determine significance (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001). IFN, interferon; IL, interleukin; MCP‐1, monocyte chemoattractant protein‐1; NS, not significant; TNF, tumor necrosis factor.