Table 3. Univariate and multivariate Cox regression analysis for relapse-free survival in luminal A breast cancer.

Clinicopathological variable	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	p-value	Hazard ratio (95% CI)	p-value
Age (yr)		0.002		0.033
≥50	Ref		Ref
<50	2.63 (1.33–5.21)		3.92 (1.12–13.77)
Tumor size (cm)		0.004		<0.001
≤2	Ref		Ref
>2	2.81 (1.39–5.69)		2.54 (1.21–5.29)
LN metastasis		0.015		<0.001
No	Ref		Ref
Yes	2.80 (1.40–5.62)		5.22 (1.68–16.18)
LVI		0.015		0.014
No	Ref		Ref
Yes	2.79 (1.39–5.60)		1.30 (1.13–6.17)
Histologic grade		0.029		0.018
Well	Ref		Ref
Moderately to poorly	2.73 (1.10–6.77)		1.56 (1.38–7.81)
BCL2 expression		0.013		0.025
Negative	Ref		Ref
Positive	0.20 (0.05–0.82)		0.07 (0.01–0.72)

CI=confidence interval; Ref=reference; LN=lymph node; LVI=lymphovascular invasion; BCL2=B-cell lymphoma 2.