Table 4.
The comparison results of the most impacted pathways and impact direction under decision analysis model, KEGG-PATH and DIA method
| KEGG pathway Categories/Sub-categories | The concordance rate of impact direction | The concordance rate of the most impacted pathways | ||||
|---|---|---|---|---|---|---|
| Decision analysis | KEGG-PATH | DIA | KEGG-PATH | |||
| 1 | 1. Metabolism | For its sub-category pathways | 54.5 %(6/11) | 45.5 %(5/11) | 62.5 % (5/8) | 87.5 %(7/8) |
| 2 | 3. Environmental Information Processing | 100 %(3/3) | 33.3 %(1/3) | 0 (0/1) | 100 %(1/1) | |
| 3 | 1.1 Carbohydrate Metabolism | For its secondary pathways | 35.7 % (5/14) | 50 %(7/14) | 40 % (2/5) | 50 % (3/6) |
| 4 | 1.2 Energy Metabolism | 33.3 %(1/3) | 33.3 %(1/3) | 100 %(2/2) | 100 %(2/2) | |
| 5 | 1.3 Lipid Metabolism | 76.9 %(10/13) | 30.8 %(4/13) | 50 %(3/6) | 33.3 %(2/6) | |
| 6 | 1.4 Nucleotide Metabolism | 50 %(1/2) | 0 (0/2) | 100 %(2/2) | 100 %(2/2) | |
| 7 | 1.5 Amino Acid Metabolism | 54.5 %(6/11) | 72.7 %(8/11) | 50 %(2/4) | 60 %(3/5) | |
| 8 | 1.6 Metabolism of Other Amino Acids | 75 %(3/4) | 75 %(3/4) | 100 %(2/2) | 100 %(2/2) | |
| 9 | 1.7 Glycan Biosynthesis and Metabolism | 58.3 %(7/12) | 41.7 %(5/12) | 50 %(2/4) | 25 %(1/4) | |
| 10 | 1.8 Metabolism of Cofactors and Vitamins | 37.5 %(3/8) | 37.5 %(3/8) | 60 %(3/5) | 60 %(3/5) | |
| 11 | 1.11 Xenobiotics Biodegradation and Metabolism | 66.7 %(2/3) | 100 %(3/3) | 50 %(1/2) | 100 %(2/2) | |
| 12 | 3.2 Signal Transduction | 63.6 %(7/11) | 63.6 %(7/11) | 60 %(3/5) | 60 %(3/5) | |
| 13 | 3.3 Signaling Molecules and Interaction | 66.7 %(2/3) | 33.3 %(1/3) | 100 %(3/3) | 100 %(3/3) | |
For the ‘The concordance rate of impact direction’ column, the denominator of each fraction in the parentheses denotes the number of subcategory pathways and the secondary pathways from the front corresponding categories and sub-categories for two columns, and the numerator of each fraction for two columns denotes the number of pathways with the same impact direction under DIA and decision analysis, and under DIA and KEGG-PATH respectively. For the ‘The concordance rate of the most impacted pathways’ column, the denominator of each fraction in the parentheses denotes the number (a) of the most impacted pathways identified based on DC values in corresponding pathway categories and sub-categories for two columns, and the numerator of each fraction for two columns denotes the number of pathways which also appeared in top a pathways identified by DIA average impact values and by total effect from KEGG-PATH, respectively