Table 2.

Summary of key characteristics of implemented models

	Model 1	Model 2	Model 3	Model 4
Outcome type	Continuous	Continuous	Continuous	Continuous
Outcome synthesised	Change from baseline	Change from baseline	Change from baseline	Final score
Approach	ANCOVA (baseline adjustment)	ANCOVA (baseline adjustment)	No baseline adjustment	No baseline adjustment
Pain interactions (case-study specific)	Yes	Yes	Yes	Yes
Further adjustments	None	Patients characteristics as treatment-effect modifiers	None	None