. Author manuscript; available in PMC: 2016 Oct 6.

Published in final edited form as: Leukemia. 2012 Jul 2;27(1):255–258. doi: 10.1038/leu.2012.173

Table 1. Association between rs6904029 and risk of chronic lymphocytic leukemia.

	GWAS			Replication			Combined^*
Genotype	Cases	Controls	OR^a (95% CI^b)	Cases	Controls	OR (95% CI)	OR (95% CI)	P_het (I²)
AA	67	213	1.94 (1.40-2.66)	100	113	1.52 (1.12-2.07)	1.71 (1.37-2.13)	0.28 (13.7%)
AG	212	1,109	1.18 (0.96-1.45)	389	613	1.09 (0.91-1.31)	1.13 (0.99-1.29)	0.57 (0.0%)
GG	223	1,375	-	408	703	-	-	-
Total	502	2,697	1.32 (1.14-1.52) per allele P_trend=1.38x10^-4	897	1,429	1.18 (1.04-1.34) per allele P_trend=0.01	1.24 (1.13-1.36) P_trend=1.00x10^-5	0.25 (25.5%)

Odds Ratio.

95% Confidence Interval.

Meta-analysis under fixed effects model. P_het, P-value for heterogeneity between studies determined from Cochran’s Q statistic. I², proportion of the total variation due to heterogeneity calculated; I² values ≥75% are considered characteristic of large heterogeneity.