Figure 6. Regional plots of 3p24.1 and 6q23.3 associations with recombination rates and chromatin state segmentation tracks.

(a) 3p24.1 and (b) 6q23.3. Association results of both genotyped (triangles) and imputed (circles) SNPs in the GWAS samples and recombination rates for rates. −log₁₀ P values (y axis) of the SNPs are shown according to their chromosomal positions (x axis). The top genotyped SNP in each combined analysis is shown as a large triangle and is labeled by its rsID. Color intensity of each symbol reflects the extent of LD with the top genotyped SNP; white (r²=0) through to dark red (r²=1.0) Genetic recombination rates, estimated using HapMap Utah residents of Western and Northern European ancestry (CEU) samples, are shown with a light blue line. Physical positions are based on NCBI Build 37 of the human genome. Also shown are the relative positions of genes and transcripts mapping to the region of association. Genes have been redrawn to show the relative positions; therefore, maps are not to physical scale. The lower panel shows the exons and introns of the gene of interest; observed SNP and chromatin state segmentation track (ChromHMM).