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. 2016 Sep 30;10:3197–3209. doi: 10.2147/DDDT.S111443

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© 2016 Ghattas et al. This work is published and licensed by Dove Medical Press Limited

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The binding site of four PTP classes exemplified by the surfaces of representative example.

Notes: Surface colors generated using MOE Pocket coloring: red, hydrophilic; gray, hydrophobic; white, neutral. (A) MPtpB (PDB: 2OZ537), structure representative of “very druggable”. (B) GLEPP-1 (PDB: 2GJT38), structure representative of “druggable”. (C) PTPε (PDB: 2JJD38), structure representative of “intermediate”. (D) JSP-1 (PDB: 1WRM39), structure representative of “difficult”.

Abbreviation: PTP, protein tyrosine phosphatase.