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Active site conformational effect on the PTP1B druggability.
Notes: (A) The active site of two crystal structures of PTP1B aligned on each other; PDB: 2HNP42 is the apo structure and shown in blue cartoon, whereas 1KAK28 is the ligand-bound structure and shown in gold cartoon. The binding pocket surface of the (B) PTP1B apo structure and (C) PTP1B ligand-bound form.
