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. Author manuscript; available in PMC: 2017 Apr 14.
Published in final edited form as: Medchemcomm. 2016 Apr 14;7:1183–1189. doi: 10.1039/C6MD00121A

Fig. 1. FGF-FGFR structure and downstream signaling pathway.

Fig. 1

The extracellular domain of FGFRs consists of three ligand binding Ig domains (IgI-III). Binding of FGFs to the FGFRs results in receptor dimerization and autophosphorylation of the tyrosine kinase (TK) domains. Upon phosphorylation, the major FGFR effector FRS2 acts as a docking site for GRB2, which then activates extracellular signal-regulated kinase (ERK) and Akt via SOS and GAB1.