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. 2016 Oct 6;12(10):e1006308. doi: 10.1371/journal.pgen.1006308

Fig 3. RL-m155 mice and miR-155 knockout (KO) mice displayed the unaltered β-cell proliferation and hormone profiles in pancreas.

Fig 3

(A) Morphology of the entire pancreas from RL-m155 mice and miR-155 KO mice. (B) Haematoxylin and eosin (H&E), insulin and glucagon stainings of pancreatic islets in RL-m155 mice and miR-155 KO mice. (C) qRT-PCR analysis of Ins1 and Ins2 mRNA expression in pancreas tissue of RL-m155 mice and miR-155 KO mice. (D) Percentage of β-cell mass in RL-m155 mice and miR-155 KO mice. (E) BrdU and Ki67 stainings of pancreatic islets in RL-m155 mice and miR-155 KO mice. (F) Percentage of Ki67-positive cells in pancreatic islets in RL-m155 mice and miR-155 KO mice. In this study, the non-transgenic littermates/wild-type littermates [i.e., control (con) mice] were used as controls of RL-m155 mice, while wild-type C57BL/6J mice (i.e., WT) of the same age and sex were used as controls of miR-155–/–C57BL/6J mice.