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. 2016 Oct 6;11(10):e0164183. doi: 10.1371/journal.pone.0164183

Fig 8. Transgenic mice overexpressing Heparanase are more sensitive to inflammatory stimuli.

Fig 8

WT and TG-HPA mice were treated with a single dose of LPS (1 mg/Kg) IP and sacrified after 6 h. (A) Analysis of Socs3 mRNA, (B) CRP mRNA and (C) HAMP1 mRNA in the liver of WT and TG-HPA mice in relation to Hprt1, before and after the treatment. The values are expressed as fold change of wild type mice. (D) Quantification of serum Hepcidin by SELDI-TOF. (E) Western blot of pSMAD5, total SMAD5, pSTAT3, total STAT3 and of GAPDH as housekeeping.