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. Author manuscript; available in PMC: 2016 Oct 6.
Published in final edited form as: DNA Repair (Amst). 2014 Jan 25;20:41–48. doi: 10.1016/j.dnarep.2013.10.012

Fig. 2.

Fig. 2

Oxidized bases recognized by the UvrABC system. While 8-oxo-dG (OG) is a poor substrate for the UvrABC system, further oxidation products of this adduct are good substrates [55]. These include, guanidinohydantoin (Gh) and the two diastereomers of spiroiminodihydantoin (Sp), and spiroiminiohydantoin-adducts: Sp-lys, Sp-GPRP, Sp-GlcN, and Sp-GPRPGP. The F, is a fluorescein-modified thymine which serves as a positive control. Numbers in boxes indicate the extent of incision of a DNA duplex containing these site-specific lesions. Adapted from [55] with permission.