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. 2016 Oct 6;11(10):e0163164. doi: 10.1371/journal.pone.0163164

Fig 7. Inhibitory receptor expression on Gag-specific IFNγ and IL-2 producing CD8+ and CD4+ T cells.

Fig 7

Panel A shows the mean fluorescent intensity (MFI) for PD1 and TIM-3 on Gag-specific CD8+ T cells. Panel B shows MFI for PD-1, CTLA-4 and TIM-3 on Gag-specific CD4+ T cells. HIV+ designates virologically suppressed, ART treated subjects undergoing therapeutic vaccination whereas HIV- designates uninfected individuals undergoing prophylactic vaccination in the HVTN 205 trial. Inhibitory receptor expression was determined for IFNγ and IL-2 responding cells, indicated below the X axis. Box plots show median values and interquartile ranges; the whiskers indicate the lowest and highest points within 1.5 interquartile ranges of the lower and higher quartiles. No significant difference in inhibitory receptor expression was found between HIV+ and HIV- subjects using Mann-Whitney T test.