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| PKR degradation | SAP30 Binding | Transcription inhibition | Inhibition of IFN-β mRNA transcription | p53 stabilization | Cytotoxicity (% cell viability) | Virulence in young mice (% survival) | |
|---|---|---|---|---|---|---|---|
| MP-12 | Yes | Yes | Strong | Strong | Strong | 10 | 45 |
| MP-12-M250K | Yes | Yes | Moderate | Strong | Moderate | 61 | 80 |
| MP-12-R16H/M250K | Yes | Yes | No inhibition | Moderate | Weak | 89 | 100 |
