Table 2. Increased relative risk for cardiovascular death by higher NT-proBNP levels.

	Hazard Ratio	95% CI	p-Value
Unadjusted	2.26	2.18 to 3.49	2.24*10−17
Model I	1.67	1.27 to 2.21	2.78*10−4
Model II	1.75	1.33 to 2.29	5.17*10−5
Model III	1.73	1.01 to 2.97	0.047

Shown are hazard ratio estimates for cardiovascular death per unit log NT-proBNP and P-values using the Cox proportional hazard regression model without and with various adjustments. Analysed are 1,223 subjects with NT-proBNP measured at baseline including 52 deaths during a long-term follow-up (median 12.9 years, min = 0.1year, max = 13.2years) in a general population 25 to 74 years of age.

Model I: Adjustment for age and sex.

Model II (Clinical risk factors): Adjustment for age, sex, serum creatinine, hypertension, diabetes, BMI and the ratio of total to high-density lipoprotein.

Model III (Clinical and echocardiographic risk factors): As Model II additionally adjusted for LVMi, EF and signs of left ventricular diastolic dysfunction (left atrial enlargement, E/A ratio below 0.75).