Table 3. Association of candidate gene variants with the presence of albuminuria.
| Gene | dbSNP ID | MAF | Albuminuria (Additive) p value | Variant frequency | Odds Ratio (C.I) | |
|---|---|---|---|---|---|---|
| Cases | Controls | |||||
| APOL1 G1 | rs73885319 | .219 | .017 | 32.0% | 20.3% | 2.51 (1.18–5.46) |
| APOL1 G2 | rs71785313 | .160 | .048 | 10.0% | 16.0% | 0.36 (0.12–0.99) |
| DARC | rs2814778 | .136 | .046 | 4.2% | 15.7% | 0.29 (0.07–0.99) |
| eNOS 4a | VNTR | .312 | .333* | 31.5% | 22.7% | - |
| eNOS | rs1799983 | .125 | .883 | 14.6% | 12.2% | 0.93 (0.36–2.43) |
| eNOS | rs2070744 | .156 | .263 | 10.4% | 16.3% | 0.58 (0.21–1.59) |
| CUBN | rs7918972 | .162 | .345 | 12.5% | 16.8% | 0.64 (0.24–1.71) |
| CUBN | rs1801239 | .027 | .199 | 0.0% | 3.1% | - |
A case:control association test was performed for each polymorphism using a correlation trend test with correction for age and sex.
*4a variant compared to all other eNOS variants.