Table 4. Enrichment analysis of key transcription factors that act on genes in green module (FDR < 0.05).
| Network | GO processes | Total nodes | Seed nodes | adjusted p-value |
|---|---|---|---|---|
| CREB1 | G1/S transition of mitotic cell cycle, metallo-and- iron-sulfur cluster assembly, | 73 | 73 | 3.980E-193 |
| c-Myc | modulation by virus of host morphology or physiology or of other organism involved in symbiotic interaction | 49 | 48 | 8.490E-124 |
| p53 | cell cycle process cellular response to glucose starvation, negative regulation of cell cycle | 20 | 19 | 4.240E-48 |
| ZNF143 | single-organism carbohydrate metabolic process, carbohydrate metabolic process, nucleotide metabolic process), nucleoside phosphate metabolic process, CMP-N-acetylneuraminate biosynthetic process | 19 | 18 | 1.550E-45 |
| GCR-alpha | cellular component organization, cellular component organization or biogenesis, cellular amino acid biosynthetic process, rhythmic process, response to arsenic-containing substance | 19 | 18 | 1.550E-45 |
| Androgen receptor | androgen receptor signaling pathway, intracellular steroid hormone receptor signaling pathway, positive regulation of transcription, DNA-dependent, positive regulation of RNA metabolic process, positive regulation of gene expression | 16 | 15 | 7.080E-38 |
| SP1 | response to arsenic-containing substance, cellular response to chemical stimulus, cellular nitrogen compound metabolic process, modulation by virus of host morphology or physiology, regulation of transcription from RNA polymerase II promoter in response to hypoxia | 15 | 14 | 2.490E-35 |
| ESR1 (nuclear) | intracellular receptor signaling pathway, RNA metabolic process, intracellular steroid hormone receptor signaling pathway, gene expression, transcription from RNA polymerase II promoter | 15 | 14 | 2.490E-35 |
| E2F1 | cell cycle process, mitotic cell cycle, negative regulation of cellular process, cell cycle, negative regulation of biological process | 14 | 13 | 8.650E-33 |
Top 10 significantly enriched transcription factor networks of the 202 annotated genes from the green module. For each network, the GO processes are shown along with the number of genes from the green network that are enriched within each network and the number of total nodes that define the network. Total nodes = total number of objects in the network (database); Seed nodes = number of objects in green dataset. Hypergeometric test adjusted for multiple comparisons using Benjamini & Hochberg (p<0.05).